Pannex Therapeutics

Pannex Therapeutics is pioneering Pannexin 1 channel blockers, a breakthrough therapeutic class with significant potential in oncology and neurology.

  • Stage Product In Development
  • Industry Biotechnology
  • Location New York, NY, USA
  • Currency USD
  • Founded May 2021
  • Employees 3
  • Incorporation Type C-corp
  • Website pannextherapeutics.com

Company Summary

Pannex Therapeutics is developing first-in-class Panx1 inhibitors targeting pathological ATP signaling, an upstream driver of neuroinflammation and tumor immune suppression. Our lead oral program (PX004) targets post-surgical neuropathic pain, enabling a rapid and capital-efficient path to clinical proof-of-mechanism, with significant expansion potential into broader pain indications and oncology through a novel immune-conditioning approach.

Team

  • Chief strategy officer

    30+ years of experience in biopharmaceuticals and venture capital.
    Executive positions at Knoll and Novartis, General Manager Actelion Pharmaceuticals.
    Expertise in drug development, commercial operations, and B&D.
    Contributed to the success of the startup Actelion, acquired for $30 bi.
    VC (FinHealth), investing in and supporting life science portfolio companies.
    PhD in Biology and a BA in Chemistry from the University of Mainz, Germany.

  • Successful serial entrepreneur in Life Sciences, founded 4 companies.
    Groundbreaking, highly cited researcher in the field of Panx1 and blocking Panx1 as a therapeutic approach, +10 years.
    Effectively translating science into products and raising funds from private and public sources.
    Ph.D. in Neuroscience from the University of Santiago, Chile.
    Received the National Prize of Innovation in Chile in 2015.

  • Gerhard Gross
    CSO

    30+ years of experience in global pharmaceutical companies in general drug development, drug discovery, screening, and profiling lead candidates.
    Key role in drug development and registration at Aventis, Novartis, AstraZeneca, Lundbeck, and Janssen.
    14 FDA-approved drugs in the market.
    Notable successes include Leflunomide, Glivec, Myfortic, Zelmac, Everolimus, and Aliskiren.
    Ph.D. in Organic Chemistry from the University of Marburg, Germany.

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