Irisin for Pancreas Life

We aim to develop a new drug to preserve and improve pancreatic islet function and survival before a transplant in order to improve islet engraftment

  • Stage Concept Only
  • Industry Biotechnology
  • Location Bari, Metropolitan City of Bari, Italy
  • Currency EUR
  • Incorporation Type Not Incorporated

Company Summary

Pancreatic islet transplantation represents the strategy closest to diabetes cure. However, islets are difficult to obtain, due to the lack of donations and high mortality rate of transplanted cells.

"Irisin for Pancreas Life" proposes the use of irisin, a hormone secreted by skeletal muscle, as a new strategy to preserve and improve pancreatic islet survival and function before a transplant, in order to improve islet engraftment.

Team

  • Francesco Giorgino
    M.D., Ph.D.; Full Professor of Endocrinology; Chairman, Department of Emergency and Organ Transplantation; Head, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro

    He directs a research laboratory in Endocrinology and Metabolic Diseases. He has published more than 150 original and review articles in prestigious scientific journals (H-index of 53, over 8,500 citations). His research interests cover various aspects of the pathophysiology of type 2 diabetes, including the mechanisms of adipose tissue and islet dysfunction and the cardiovascular effects of new therapeutic agents in this disease condition.

  • Annalisa Natalicchio
    M.D., Ph.D.; Assistant Professor of Endocrinology, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro

    She has many years of experience in the field of endocrinological research. She has published numerous original and review articles in prestigious scientific journals (H-index of 21, over 1,700 citations). To date, she supervises a line of research that aims to study the molecular mechanisms underlying the physiopathology of pancreatic islets under dismetabolic conditions and to identify new therapeutic agents.

  • Nicola Marrano
    M.S., Ph.D.; Post-doc Fellow, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro

    He is maturing experience in the field of basic endocrinological research. He has published several original articles in prestigious scientific journals. His expertise concerns the study of biological and biochemical processes, in cell cultures and laboratory animals, in physiological and pathological conditions.

Advisors

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