Contactually is an automatic way to prioritize your email contacts and reconnect with the right person at the right time. We integrate well with other CRMs (Highrise, Salesforce) or work as a stand-alone app, and sales and biz dev folks -- really anyone that emails a lot of new people -- love what we're trying to do.
We flip the existing approach to CRM on its head by focusing on the end-user experience, through an email-centric workflow.